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New PDF release: Fetal-Placental Disorders

By Nicholas S. Assali (Eds.)

ISBN-10: 0120655020

ISBN-13: 9780120655021

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Example text

DISORDERS OF PLACENTAL TRANSFER 21 2 . RIBOFLAVIN (VITAMIN Bg) Riboflavin is also present in fetal blood in higher concentrations than in maternal blood. Lust et al. {218) found that flavin adenine dinucleotide, a riboflavin precursor, was converted to free riboflavin in crossing the placenta. These authors demonstrated that while the concentration of total riboflavin in fetal blood was only slightly greater than that in maternal blood, the fetal free riboflavin concentration was about five times that of the maternal concentration.

19. Ratio of mean placental to fetal weight during the last half of human pregnancy, from the data of Shankhn for two population groups (303, 304). The mean "normal" and "critical" placental/fetal weights for the two groups are shown by the shaded areas. The "critical" placental/fetal weight is the ratio below which the infant will probably not survive. measurements of placental volume in a single pregnancy from 10 weeks to term, using a B-mode scan ultrasound. The standard deviation in their measurement was rather large, however, and the value of this procedure for accurate measurements remains to be demonstrated.

Electron microscopy reveals small irregular cytoplasmic projections or "microvilli" (Figs. 13 and 14). The nuclei of the early syncytiotrophoblast are large and rather evenly spaced. The syncytioplasm contains numerous mitochondria and vacuoles (Fig. 15). As gestation proceeds, the cells become progressively thinner (Figs. 16 and 17). In some regions they tend to clump into knots, and in other areas the thickness decreases markedly to form "vasculosyncytial membranes" (111). The average thickness decreases from ^^20 to 4 μ.

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Fetal-Placental Disorders by Nicholas S. Assali (Eds.)


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